AMD GPU architecture documentation

This page collects AMD GPU architecture documentation in one place, including instruction set architecture (ISA) references, white papers, microarchitecture overviews, and performance counter documentation for AMD Instinct™ and Radeon™ GPU families.

These documents can be useful when studying hardware capabilities, tuning kernel performance, interpreting profiling data, or understanding low-level architectural behavior.

CDNA™ 4 (AMD Instinct MI350 Series)

• AMD CDNA 4 (Instinct MI350 Series) ISA reference

• White paper

• Performance counters

CDNA 3 (AMD Instinct MI300 Series)

• AMD CDNA 3 (Instinct MI300 Series) ISA reference

• White paper

• AMD Instinct MI300 microarchitecture

• Performance counters

CDNA 2 (AMD Instinct MI200 Series)

• AMD CDNA 2 (Instinct MI200 Series) ISA reference

• White paper

• AMD Instinct MI250 microarchitecture

• Performance counters

CDNA (Instinct MI100)

• AMD CDNA (AMD Instinct MI100) ISA reference

• AMD Instinct MI100 microarchitecture

• White paper

RDNA™ (Radeon and Ryzen)

• AMD RDNA 4 ISA reference

• AMD RDNA 3 ISA reference

• AMD RDNA 2 ISA reference

• AMD RDNA ISA reference

Older architectures

• AMD Vega 7nm (Instinct MI50) ISA reference

• AMD Vega (Instinct MI25) ISA reference

• AMD GCN 3 ISA reference